Horizontal Transmission of a Hepatitis B Virus Surface Antigen Mutant
نویسندگان
چکیده
منابع مشابه
Horizontal transmission of a hepatitis B virus surface antigen mutant.
The envelope protein of hepatitis B virus (HBV) is referred to as the HBV surface antigen (HBsAg) (8). The antigenic “a” determinant is located from residue 124 to 147 of HBsAg and is involved in eliciting antibody production. Neutralizing antibodies (anti-HBs) target the “a” determinant and generally lead to the disappearance of HBV (1). The coexistence of HBsAg and anti-HBs has been associate...
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The genome of HB V virus of serotype ayw cloned in pBR322 and expression shuttle vector p YES2 were used for construction of the HBsAg chimeric genes and their expression in Saccharomyces cerevisiae. Two recombinant plasmids were constructed. One of them contained the coding sequences for the major polypeptide of surface antigen. Another construct carried the major polypeptide with the pre-S2 a...
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Mutation in the hepatitis B virus surface antigen (HBsAg) may affect the efficiency of diagnostic immunoassays or success of vaccinations using HBsAg. Thus, antigenicity and immunogenicity analyses of the mutated HBsAg are necessary to develop novel diagnostic tools and efficient vaccinations. Here, the in vitro antigenicity of three wild-type HBsAg open reading frames (ORFs) (adr4, W1S [subtyp...
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Hepatitis B virus infection is a serious health problem worldwide, and more than 350 million people are chronic carriers, constituting a major global threat. Southeast Asia and the Western Pacific have the highest levels of endemicity in the world, with an estimated seroprevalence ranging between 2% and 31%. Mutations in the hepatitis B surface antigen (HBsAg) have been reported in many parts o...
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ژورنال
عنوان ژورنال: Journal of Clinical Microbiology
سال: 2000
ISSN: 0095-1137,1098-660X
DOI: 10.1128/jcm.38.2.938-939.2000